Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC Related Products (95):

By Effects:	Inhibitors (3) Chemicals (3)

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

FN-1501-propionic acid	2408642-48-6
FN-1501-propionic acid is a CDK2/9 ligand for PROTAC. FN-1501-propionic acid and a CRBN ligand have been used to design PROTAC CDK2/9 degrader (HY-130709).

HY-44012

SMARCA-BD ligand 1 for Protac 1997319-92-2

SMARCA-BD ligand 1 for Protac is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.

SMARCA-BD ligand 1 for Protac	1997319-92-2
SMARCA-BD ligand 1 for Protac is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.

Ipatasertib-NH2 dihydrochloride	1001264-73-8
Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase.

N-Deshydroxyethyl Dasatinib-d₈	1189998-96-6
N-Deshydroxyethyl Dasatinib-d₈ is the deuterium labeled N-Deshydroxyethyl Dasatinib. N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825), the Dasatinib-based moiety, binds to IAP ligand via a linker to form SNIPER to degrade ABL[1].

HY-111852

GNF5-amido-Me 778277-37-5

GNF5-amido-Me, the GNF5 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER.
HY-130852

CDK9-IN-11 2748368-15-0

CDK9-IN-11 is a potent CDK9 inhibitor. CDK9-IN-11 is the ligand for the PROTAC CDK9 Degrader-1 (HY-103628).
HY-151476

GID4 Ligand 2 3031442-90-4

GID4 Ligand 2 (compound 67) is a selective GID4 binder (IC₅₀=18.9 μM; K_d=17 μM). GID4 Ligand 2 can be used for the synthesis of PROTACs.

GNF5-amido-Me	778277-37-5
GNF5-amido-Me, the GNF5 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER.

CDK9-IN-11	2748368-15-0
CDK9-IN-11 is a potent CDK9 inhibitor. CDK9-IN-11 is the ligand for the PROTAC CDK9 Degrader-1 (HY-103628).

GID4 Ligand 2	3031442-90-4
GID4 Ligand 2 (compound 67) is a selective GID4 binder (IC₅₀=18.9 μM; K_d=17 μM). GID4 Ligand 2 can be used for the synthesis of PROTACs.

SMARCA-BD ligand 1 for Protac hydrochloride	2380272-56-8	99.23%
SMARCA-BD ligand 1 hydrochloride for Protac is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.

HY-115729A

(R)-PROTAC CDK9 ligand-1 2411021-95-7

(R)-PROTAC CDK9 ligand-1 (Compound 19.4) is a CDK9-targeting degrader that can be used to synthesize PROTAC with antitumor activity.
HY-107444

PROTAC Her3-binding moiety 1 1603845-36-8

PROTAC HER3-binding moiety 1 (compound 1b) is a Her3 Ligand for PROTAC.
HY-111849

Imatinib carbaldehyde 1436868-85-7

Imatinib carbaldehyde (CGP-57148B carbaldehyde), the Imatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER.

(R)-PROTAC CDK9 ligand-1	2411021-95-7
(R)-PROTAC CDK9 ligand-1 (Compound 19.4) is a CDK9-targeting degrader that can be used to synthesize PROTAC with antitumor activity.

PROTAC Her3-binding moiety 1	1603845-36-8
PROTAC HER3-binding moiety 1 (compound 1b) is a Her3 Ligand for PROTAC.

Imatinib carbaldehyde	1436868-85-7
Imatinib carbaldehyde (CGP-57148B carbaldehyde), the Imatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER.

OICR-9429-N-C2-NH2	2407457-55-8
OICR-9429-N-C2-NH2 is a ligand for Wd40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1, intermediate 2. OICR-9429-N-C2-NH2 can be used in the synthesis of PROTACs.

GID4 Ligand 1	3031442-96-0
GID4 Ligand 1 (compound 88) is a cell-permeable and high-selective GID4 binder (IC₅₀=5.4 μM; K_d=5.6 μM), binds to GID4 in cells (EC₅₀=558 nM). GID4 Ligand 1 can be used for the synthesis of PROTACs.

HY-160151

TP1L

TP1L is a selective TC-PTP PROTAC degrader for cancer immunotherapy with a DC50 value of 35.8 nM.

TP1L
TP1L is a selective TC-PTP PROTAC degrader for cancer immunotherapy with a DC50 value of 35.8 nM.

BCN-sulfonamide-PEG2-sulfonamide-N-bis(ethanol)	2126749-81-1
BCN-sulfonamide-PEG2-sulfonamide-N-bis ethanol (compound 71) is a Ligands for Target Protein for PROTAC that contains a sulfonamide linker to increase the solubility of the linker-conjugate. BCN-sulfonamide-PEG2-sulfonamide-N-bis ethanol can be used to synthesize PROTACs with antitumor activity.

HY-46340

AZD9496 deacrylic acid phenol 2173404-70-9

AZD9496 deacrylic acid phenol is a fragment of target protein ligand of PROTAC ER Degrader-4 (HY-135309).

AZD9496 deacrylic acid phenol	2173404-70-9
AZD9496 deacrylic acid phenol is a fragment of target protein ligand of PROTAC ER Degrader-4 (HY-135309).

PROTAC PARP/EGFR ligand 1	2661609-57-8
PROTAC PARP/EGFR ligand 1 is an active compound that can be used for the synthesis of dual PARP EGFR degraders by proteolytic targeting chimera (PROTAC) technology.

HY-158433

KDM5B ligand 2

KDM5B ligand 2 is the ligand for target protein KDM5B. KDM5B ligand 2 is utilized for synthesis of KDM5B PROTAC GT-653 (HY-158432).
HY-111843

Ch55-O-C3-NH2 144298-98-6

Ch55-O-C3-NH2 (RAR ligand 1) is a Ch 55-based ligand, which targets RAR. Ch55-O-C3-NH2 (RAR ligand 1) binds to cIAP1 ligand Bestatin via a linker to form SNIPER.

KDM5B ligand 2
KDM5B ligand 2 is the ligand for target protein KDM5B. KDM5B ligand 2 is utilized for synthesis of KDM5B PROTAC GT-653 (HY-158432).

Ch55-O-C3-NH2	144298-98-6
Ch55-O-C3-NH2 (RAR ligand 1) is a Ch 55-based ligand, which targets RAR. Ch55-O-C3-NH2 (RAR ligand 1) binds to cIAP1 ligand Bestatin via a linker to form SNIPER.

PROTAC BRD9-binding moiety 5	893633-37-9
PROTAC BRD9-binding moiety 5 is a selective BRD9 binder with an IC₅₀ value of 4.20 μM, can be used for the synthesis of PROTACs. PROTAC BRD9-binding moiety 5 has antiproliferative activity against cancer cells.

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